Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.
Nat Med
; 5(11): 1270-6, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10545993
ABSTRACT
Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Produtos do Gene env
/
Produtos do Gene nef
/
Vírus da Imunodeficiência Símia
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article