Use of idarubicin in pre-transplant conditioning in children with high-risk acute leukaemia.
Bone Marrow Transplant
; 24(9): 953-8, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10556953
ABSTRACT
The major cause of treatment failure following allogeneic bone marrow transplantation for acute leukaemia is disease relapse. In an attempt to reduce post- transplant relapse in 33 children with high-risk acute leukaemia who received a related or unrelated bone marrow transplant, the pre-transplant conditioning regimen was intensified by the addition of idarubicin. Its toxicity and effects on survival were evaluated over a 57-month period. Toxicity, largely gastrointestinal, was increased but acceptable, and there was no specific regimen-related toxicity. Relapse rates were low (24%) in this high risk group, but mortality was increased in those receiving unrelated donor grafts, largely due to sepsis. Idarubicin does appear to have a role to play in the conditioning regimen of patients with high-risk acute leukaemia undergoing BMT, and may reduce relapse rates without increasing transplant-related mortality.
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Base de dados:
MEDLINE
Assunto principal:
Idarubicina
/
Leucemia
/
Transplante de Medula Óssea
/
Condicionamento Pré-Transplante
/
Antibióticos Antineoplásicos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article