NADPH-diaphorase-containing neurons in cortex, subcortical white matter and neostriatum are selectively spared in Alzheimer's disease.
Dement Geriatr Cogn Disord
; 10(6): 460-8, 1999.
Article
em En
| MEDLINE
| ID: mdl-10559560
ABSTRACT
To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and atrophy in the cortex of AD. Despite slight morphological neuronal changes in the cortex of AD, we found no significant difference in the number of NADPH-d-positive neurons in both cortex and neostriatum between control and AD cases. These results provide further evidence for a selective preservation of NADPH-d neurons in AD. In order to check whether nNOS-immunoreactive neurons are identical to NADPH-d-positive neurons in the human brain, we examined the frontal and temporal cortex and neostriatum of normal human brains in serial cryostat sections. We found that nNOS-containing neurons paralleled NADPH-d-positive neurons in these brain regions. Copyrightz1999S.KargerAG,Basel
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Córtex Cerebral
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Neostriado
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Doença de Alzheimer
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NADPH Desidrogenase
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Neurônios
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article