Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.
Nat Cell Biol
; 1(2): 113-8, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10559883
ABSTRACT
The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann-Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC.
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Base de dados:
MEDLINE
Assunto principal:
Endossomos
/
Pele
/
Lisofosfolipídeos
/
Doenças de Niemann-Pick
/
Colesterol
/
Membranas Intracelulares
/
Lipídeos de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article