Haem oxygenase-1 prevents cell death by regulating cellular iron.
Nat Cell Biol
; 1(3): 152-7, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10559901
ABSTRACT
Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1 cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Apoptose
/
Heme Oxigenase (Desciclizante)
/
Ferro
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article