The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.
Bioorg Med Chem Lett
; 9(21): 3137-42, 1999 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-10560740
ABSTRACT
Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
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Base de dados:
MEDLINE
Assunto principal:
Serina Endopeptidases
/
Inibidores de Serina Proteinase
/
Citomegalovirus
/
Hidroxilaminas
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article