Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Science
; 286(5445): 1738-41, 1999 Nov 26.
Article
em En
| MEDLINE
| ID: mdl-10576741
ABSTRACT
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase or ERK kinase, and PI3K is phosphatidylinositol 3-kinase). However, these two signaling pathways were shown to exert opposing effects on muscle cell hypertrophy. Furthermore, the PI3K-Akt pathway was shown to inhibit the Raf-MEK-ERK pathway; this cross-regulation depended on the differentiation state of the cell Akt activation inhibited the Raf-MEK-ERK pathway in differentiated myotubes, but not in their myoblast precursors. The stage-specific inhibitory action of Akt correlated with its stage-specific ability to form a complex with Raf, suggesting the existence of differentially expressed mediators of an inhibitory Akt-Raf complex.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas
/
Proteínas Serina-Treonina Quinases
/
Músculo Esquelético
/
Proteínas Proto-Oncogênicas c-raf
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article