Ventral neuroblasts and the heartless FGF receptor are required for muscle founder cell specification in Drosophila.
Oncogene
; 18(48): 6818-23, 1999 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-10597291
ABSTRACT
Muscle founder cells are uniquely specified cells that fuse with neighboring myoblasts to generate the complex pattern of body wall muscles in the Drosophila embryo. We have investigated the positional specification of founder cells for ventral oblique muscles, marked by the restricted expression of tinman RNA and the activity of a D-mef2 enhancer. The formation of these ventral myoblasts requires the function of the Heartless FGF receptor in the mesoderm and the presence of ventral neuroblasts in the central nervous system. Overproduction of ventral neuroblasts due to the forced expression of the homeodomain protein Vnd leads to increased numbers of founder cells. These results suggest the use of a neuroectoderm-to-mesoderm signaling pathway in the specification of ventral muscle precursors.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Proteínas de Drosophila
/
Drosophila
/
Músculos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article