Scopolamine augments transient auditory 40-hz magnetic response in humans.
Neurosci Lett
; 277(2): 115-8, 1999 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-10624823
ABSTRACT
The influence of neocortical muscarinic transmission on auditory-evoked 40-Hz magnetic response was studied in 13 healthy subjects in a double-blind randomized cross-over design. Either a centrally (scopolamine hydrobromide, 0.3 mg, i.v.) or a peripherally (glycopyrrolate, 0.2 mg, i.v.) acting antagonist of muscarinic transmission was administered during two sessions of magnetoencephalographic recording of 40-Hz response elicited by monaural tones. Scopolamine significantly (P < 0.01) augmented the 40-Hz magnetic response over the hemispheres ipsi- and contralateral to the ear stimulated. This finding suggests muscarinic modulation of the auditory evoked transient 40-Hz response.
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Base de dados:
MEDLINE
Assunto principal:
Escopolamina
/
Magnetoencefalografia
/
Antagonistas Muscarínicos
/
Potenciais Evocados Auditivos
/
Glicopirrolato
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article