Massive noninflammatory periportal liver necrosis following concentrated acetic acid ingestion.
Arch Pathol Lab Med
; 124(1): 127-9, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10629144
ABSTRACT
In a fatal occurrence of massive liver necrosis following ingestion of concentrated (90%) acetic acid, the patient showed evidence of hemolysis, disseminated intravascular coagulation, and liver dysfunction at only 45 minutes after exposure. With refractory to vigorous supportive care, the patient s condition deteriorated until death occurred 39 hours after ingestion, despite some improvement of coagulopathy. Autopsy revealed corrosive injuries in the upper gastrointestinal tract and massive hepatic necrosis in a periportal distribution without significant inflammation. A direct effect of the noxious agent on hepatocytes involving the portal circulation is suggested.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Acético
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article