Requirement of CD9 on the egg plasma membrane for fertilization.
Science
; 287(5451): 321-4, 2000 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-10634791
ABSTRACT
CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Interações Espermatozoide-Óvulo
/
Glicoproteínas de Membrana
/
Antígenos CD
/
Infertilidade Feminina
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article