Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients.
Biol Psychiatry
; 47(1): 29-33, 2000 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-10650446
ABSTRACT
BACKGROUND:
The soluble intercellular adhesion molecule-1 (sICAM-1) is a marker for the activation of the cellular immune system. Since an activation of the immune system has been observed in a part of the schizophrenic patients, we measured the serum levels of soluble ICAM-1 (sICAM-1) in schizophrenic patients and correlated them to the patient's psychopathology.METHODS:
To monitor a possible effect of antipsychotic therapy, 36 schizophrenic patients were examined twice first without antipsychotic medication immediately after admission to the hospital and then, after clinical improvement before discharge. The results were compared with those of 36 age- and gender-related healthy individuals.RESULTS:
The schizophrenic patients showed significantly decreased serum levels of sICAM-1 at the first examination (248 +/- 95 ng/mL) and at re-examination (266 +/- 95 ng/mL) compared with the comparison group (323 +/- 74 ng/mL). Patients with more pronounced negative symptoms showed higher levels of sICAM-1 at the first examination.CONCLUSIONS:
We conclude that reduced sICAM-1 levels in schizophrenia indicate a reduced activity of the cellular immune system in at least a subgroup of schizophrenic patients.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Barreira Hematoencefálica
/
Molécula 1 de Adesão Intercelular
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article