[A case of significant natriuresis and improvement of proteinuria by Temocapril, an ACE inhibitor with biliary excretion, in loop diuretics resistant edema in membranous nephropathy].
Nihon Jinzo Gakkai Shi
; 41(8): 813-7, 1999 Dec.
Article
em Ja
| MEDLINE
| ID: mdl-10655730
ABSTRACT
A 50-year-old man with WPW syndrome and chronic atrial fibrillation controlled by digoxin exhibited nephrotic syndrome due to membranous nephropathy in 1994. For massive edema resistant to loop diuretics, administration of 2 mg/day of Temocapril, an ACE inhibitor with biliary excretion, was started. It provided marked natriuresis and rapid improvement of massive anasarca. Moreover, 6 months later at the time of writing this report, nephrotic proteinuria has decreased and abnormally depressed Ccr level has elevated. For massive edema resistant to loop diuretics in nephrotic syndrome, Temocapril might bring about a beneficial effect possibly through the induction of natriuresis, which has been suppressed by the over-expression of angiotensin II in tubulointerstitium.
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Base de dados:
MEDLINE
Assunto principal:
Proteinúria
/
Tiazepinas
/
Inibidores da Enzima Conversora de Angiotensina
/
Glomerulonefrite Membranosa
/
Diuréticos
/
Edema
/
Natriurese
Limite:
Humans
/
Male
/
Middle aged
Idioma:
Ja
Ano de publicação:
1999
Tipo de documento:
Article