Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease.
Hum Pathol
; 31(1): 126-8, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10665925
ABSTRACT
Benign metastasizing leiomyoma (BML) is a rare condition, characterized by the occurrence of multiple smooth-muscle nodules, most often located in the lung after previous hysterectomy because of histologically benign appearing leiomyoma. Although the condition resembles a metastatic process, case studies provided evidence that it may be the result of an intravenous leiomyomatosis or an independent and multifocal smooth-muscle proliferation. Comparative genomic hybridization and X-chromosome inactivation analysis were used in a case of BML to determine whether pulmonary and uterine tumors are related one to another. A balanced karyotype, previously reported in leiomyomas and an identical X-chromosome inactivation pattern found in all tumorlets, is most consistent with a monoclonal origin of both uterine and pulmonary tumors and the interpretation that pulmonary lesions are metastatic.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uterinas
/
Leiomioma
/
Neoplasias Pulmonares
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article