Partial synergy of bisindolylmaleimide with apoptotic stimulus in antigen-specific T cells--implications for multiple sclerosis.
J Neuroimmunol
; 103(1): 69-75, 2000 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-10674991
ABSTRACT
In multiple sclerosis (MS), induction of T cell apoptosis constitutes a promising therapeutic strategy. Recently, bisindolylmaleimide has been shown to be an effective treatment of experimental autoimmune encephalomyelitis, presumably due to enhancement of CD95-mediated T cell apoptosis. Therefore, we studied the effects of bisindolylmaleimide on human (auto)antigen-specific T cells. We observed a synergistic effect of bisindolylmaleimide with apoptotic stimulus assessed via caspase activity and annexin V-binding, but no potentiation of DNA fragmentation or cell death. Thus, bisindolylmaleimide might be useful for modulating T cell apoptosis, yet more potent substances have to be generated re-establishing immunological control over auto-reactive T cells.
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Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Linfócitos T
/
Apoptose
/
Receptor fas
/
Inibidores Enzimáticos
/
Indóis
/
Maleimidas
/
Esclerose Múltipla
/
Antígenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article