Linkage of mood disorders with D2, D3 and TH genes: a multicenter study.
J Affect Disord
; 58(1): 51-61, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10760558
BACKGROUND: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). METHODS: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. RESULTS: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. CONCLUSION: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Tirosina 3-Mono-Oxigenase
/
Transtorno Bipolar
/
Receptores de Dopamina D2
/
Transtorno Depressivo Maior
/
Ligação Genética
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article