Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay.
Mutat Res
; 467(1): 11-9, 2000 Apr 13.
Article
em En
| MEDLINE
| ID: mdl-10771267
ABSTRACT
Statistical features of a base-specific Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific Salmonella (Ames II) strains with those of traditional tester strains. In addition to using different Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Salmonella typhimurium
/
Testes de Mutagenicidade
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article