Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
Cancer Lett
; 152(2): 211-6, 2000 May 01.
Article
em En
| MEDLINE
| ID: mdl-10773414
ABSTRACT
Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study. To examine whether phenolphthalein carcinogenic potential can be detected in male and female transgenic (Tg) mice carrying the human c-Ha-ras gene (rasH2 mice) and their wild-type littermates (non-Tg mice), a diet containing 3000, 6000 or 12000 ppm was given for 6 months. Unequivocal induction of neoplastic lesions was not apparent, suggesting that rasH2 mice are resistant to the induction of malignant lymphomas by the treatment of phenolphthalein.
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Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Testes de Carcinogenicidade
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Genes ras
/
Fenolftaleína
/
Linfoma
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article