Equine influenza vaccine efficacy: the significance of antigenic variation.
Vet Microbiol
; 74(1-2): 173-7, 2000 May 22.
Article
em En
| MEDLINE
| ID: mdl-10799789
To investigate the level of cross-protection induced by equine influenza H3N8 vaccines derived from different lineages, two studies have been carried out with ponies vaccinated with 'American-like' and 'European-like' vaccines and experimentally challenged with a European-like strain. The results demonstrated that equine influenza vaccines clearly protect against challenge with homologous virus if serum antibody titres are sufficiently high. On the other hand, protection is incomplete even when animals vaccinated with heterologous strains have comparative antibody levels. Nevertheless, the protection afforded by heterologous viruses can be improved by stimulating high levels of antibody. It would be advisable to update equine influenza vaccine strains regularly so that they contain similar strains to variants that are circulating in the field.
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Variação Antigênica
/
Vacinas contra Influenza
/
Infecções por Orthomyxoviridae
/
Doenças dos Cavalos
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article