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Centromeres: getting a grip of chromosomes.
Pidoux, A L; Allshire, R C.
Afiliação
  • Pidoux AL; Human Genetics Unit, Medical Research Council, Western General Hospital, Edinburgh, EH4 2XU, UK. alison.pidoux@hgu.mrc.ac.uk
Curr Opin Cell Biol ; 12(3): 308-19, 2000 Jun.
Article em En | MEDLINE | ID: mdl-10801468
On monocentric chromosomes the centromere is the chromosomal site at which the kinetochore complex is assembled. This complex mediates the attachment and movement of chromosomes along spindle microtubules. The centromere is usually the last site to retain cohesion between sister centromeres. The location of the main sensor for defective spindle assembly at the kinetochore allows the release of this cohesion, and thus progression through mitosis, to be held in check until key events have been completed. The intricate nature of the centromere-kinetochore complexes and the events they co-ordinate and react to is presently being dissected by studies in several organisms. In particular, several new kinetochore proteins have been identified in many organisms over the last year.
Assuntos
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Base de dados: MEDLINE Assunto principal: Centrômero / Cromossomos Limite: Animals / Humans Idioma: En Ano de publicação: 2000 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Centrômero / Cromossomos Limite: Animals / Humans Idioma: En Ano de publicação: 2000 Tipo de documento: Article