Long-term treatment with SR141716A, the CB1 receptor antagonist, influences morphine withdrawal syndrome.
Life Sci
; 66(22): 2213-9, 2000 Apr 21.
Article
em En
| MEDLINE
| ID: mdl-10834304
ABSTRACT
The role of the cannabinoid system in morphine withdrawal was examined through long-term CB1 receptor antagonist administration in morphine pellet implanted rats. SR141716A chronic treatment (5mg/kg i.p. twice a day for four days) did not influence the development of tolerance to the morphine analgesic effect but significantly reduced the intensity of naloxone-induced opiate withdrawal in tolerant rats Specifically there was a significant reduction in the number of digging, teeth chattering and penile licking and the incidence of diarrhoea while other signs such as writhing, head dog shakes and rearing were unaffected. These results suggest that the pharmacological treatment with SR141716A could be of some interest in ameliorating opiate withdrawal syndrome.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Pirazóis
/
Receptores de Droga
/
Síndrome de Abstinência a Substâncias
/
Morfina
/
Dependência de Morfina
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article