Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine.
Am J Clin Nutr
; 71(6): 1511-5, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10837292
ABSTRACT
BACKGROUND:
The effects of food restriction on energy metabolism have been under investigation for more than a century. Data obtained are conflicting and research has failed to provide conclusive results.OBJECTIVE:
The objective of this study was to test the hypothesis that in lean subjects under normal living conditions, short-term starvation leads to an increase in serum concentrations of catecholamines and thus to an increase in resting energy expenditure.DESIGN:
Resting energy expenditure, measured by indirect calorimetry, and hormone and substrate concentrations were measured in 11 healthy, lean subjects on days 1, 2, 3, and 4 of an 84-h starvation period.RESULTS:
Resting energy expenditure increased significantly from 3.97 +/- 0.9 kJ/min on day 1 to 4.53 +/- 0.9 kJ/min on day 3 (P < 0.05). The increase in resting energy expenditure was associated with an increase in the norepinephrine concentration from 1716. +/- 574 pmol/L on day 1 to 3728 +/- 1636 pmol/L on day 4 (P < 0.05). Serum glucose decreased from 4.9 +/- 0.5 to 3.5 +/- 0.5 mmol/L (P < 0.05), whereas insulin did not change significantly.CONCLUSIONS:
Resting energy expenditure increases in early starvation, accompanied by an increase in plasma norepinephrine. This increase in norepinephrine seems to be due to a decline in serum glucose and may be the initial signal for metabolic changes in early starvation.
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Base de dados:
MEDLINE
Assunto principal:
Inanição
/
Norepinefrina
/
Metabolismo Energético
Tipo de estudo:
Health_economic_evaluation
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article