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Relation of serum retinol to acute phase proteins and malarial morbidity in Papua New Guinea children.
Rosales, F J; Topping, J D; Smith, J E; Shankar, A H; Ross, A C.
Afiliação
  • Rosales FJ; Nutrition and Veterinary Science Departments, The Pennsylvania State University, University Park, PA 16802, USA. fxr5@psu.edu
Am J Clin Nutr ; 71(6): 1582-8, 2000 Jun.
Article em En | MEDLINE | ID: mdl-10837302
BACKGROUND: Acute phase proteins (APPs) are associated with malaria-induced hyporetinemia (serum retinol <0.70 micromol/L); however, the degree of the association is not well documented. OBJECTIVE: The association between malaria-induced hyporetinemia and APPs was assessed. DESIGN: In a cross-sectional study, 90 children with serum retinol concentrations from <0.35 to >1.05 micromol/L were selected from children in a clinical trial of vitamin A supplementation. Serum was collected before treatment allocation. Retinol binding protein (RBP) concentrations were determined by radioimmunoassays, and transthyretin, alpha(1)-acid glycoprotein (AGP), alpha(1)-antichymotrypsin, C-reactive protein (CRP), haptoglobin, and albumin concentrations by radial immunodiffusion assays. RESULTS: Children in the subsample had high rates of splenomegaly and Plasmodium-positive blood-smear slides (P < 0.01); AGP (Pearson's r = -0.40, P < 0.001) and CRP (r = -0.21, P = 0.04) were inversely correlated with retinol. The negative APPs RBP, transthyretin, and albumin were positively and significantly associated with retinol. All APPs, except alpha(1)-antichymotrypsin, were significantly correlated with splenomegaly. Of the positive APPs, AGP correlated with CRP (r = 0.37, P < 0.001), indicating chronic inflammation. In a stepwise regression analysis, 73% of retinol's variability was explained by RBP and transthyretin. The model predicted that a 1-SD increase in RBP or transthyretin increases retinol by approximately 0.38 or 0.47 micromol/L, respectively, whereas an equivalent increase in AGP decreases retinol by 0.12 micromol/L. CONCLUSIONS: The RBP-transthyretin transport complex of retinol is not altered by inflammation. Positive APPs are useful markers of type and severity of inflammation; however, except for AGP, it is unlikely that they can correct for malaria-induced hyporetinemia.
Assuntos
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Base de dados: MEDLINE Assunto principal: Vitamina A / Proteínas de Fase Aguda / Malária Falciparum Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2000 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Vitamina A / Proteínas de Fase Aguda / Malária Falciparum Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2000 Tipo de documento: Article