Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.
Science
; 288(5474): 2215-9, 2000 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-10864871
ABSTRACT
Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.
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Base de dados:
MEDLINE
Assunto principal:
Schizosaccharomyces
/
Proteínas Fúngicas
/
Proteínas Cromossômicas não Histona
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Ciclo Celular
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Centrômero
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Segregação de Cromossomos
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Proteínas de Schizosaccharomyces pombe
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article