The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification.
Development
; 127(18): 4073-81, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10952904
ABSTRACT
The dHAND basic helix-loop-helix transcription factor is expressed in neurons of sympathetic ganglia and has previously been shown to induce the differentiation of catecholaminergic neurons in avian neural crest cultures. We now demonstrate that dHAND expression is sufficient to elicit the generation of ectopic sympathetic neurons in vivo. The expression of the dHAND gene is controlled by bone morphogenetic proteins (BMPs), as suggested by BMP4 overexpression in vivo and in vitro, and by noggin-mediated inhibition of BMP function in vivo. The timing of dHAND expression in sympathetic ganglion primordia, together with the induction of dHAND expression in response to Phox2b implicate a role for dHAND as transcriptional regulator downstream of Phox2b in BMP-induced sympathetic neuron differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Diferenciação Celular
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteínas Morfogenéticas Ósseas
/
Proteínas Aviárias
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Proteínas de Ligação a DNA
/
Gânglios Simpáticos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article