Progestin-induced mammary growth hormone (GH) production.
Adv Exp Med Biol
; 480: 71-6, 2000.
Article
em En
| MEDLINE
| ID: mdl-10959411
ABSTRACT
Toxicity studies using beagle dogs revealed in the 1980s that synthetic progestins may induce a syndrome of growth hormone (GH) excess, known as acromegaly, and the development of predominantly benign mammary hyperplasia. In the early 1990s is was discovered that progestin-induced GH excess in the dog originates within the mammary gland. This mammary-derived GH may have endocrine, para/autocrine as well as exocrine effects. The expression of GH mRNA is also found in cats and humans indicating that mammary GH expression is not unique for the dog. The mammary gene is identical to the pituitary-expressed gene and uses the same promoter. Nevertheless a striking difference exists in the mammary gland. Pit-1, which is a prerequisite factor for pituitary GH mRNA expression, is likely not involved in the mammary gene expression. These studies shed new light on the mechanism of progesterone-induced mammary hyperplasia and urges for further research on potential adverse effects of synthetic progestins.
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Base de dados:
MEDLINE
Assunto principal:
Progestinas
/
Hormônio do Crescimento
/
Glândulas Mamárias Animais
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article