The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function.
J Auton Pharmacol
; 19(6): 327-33, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10961738
ABSTRACT
1. This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/Cl(-)-dependent noradrenaline transporter (hNAT) and its gene. 2. Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
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Base de dados:
MEDLINE
Assunto principal:
Monoaminas Biogênicas
/
Proteínas de Transporte
/
Neurotransmissores
/
Simportadores
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article