1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.
Bioorg Med Chem Lett
; 10(16): 1863-6, 2000 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-10969986
ABSTRACT
Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation.
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas da Serotonina
/
Receptores de Serotonina
/
Aminopiridinas
/
Indóis
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article