Phosphatidylserine reverses reserpine-induced amnesia.
Eur J Pharmacol
; 404(1-2): 161-7, 2000 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-10980275
ABSTRACT
The effects of phosphatidylserine (PS) were studied in rats treated with reserpine (1 mg/kg) immediately after training in the passive avoidance task. In experiment I, phosphatidylserine (25 mg/kg) was administered 30 min before or immediately after training. Acute pre- or post-treatment with phosphatidylserine was effective in reversing the amnestic effect of reserpine in test trials performed 24 h and 1 week after training. Experiment II was performed to determine if the long-term pretreatment with phosphatidylserine (25 mg/kg) for 7 days is able to protect the rats against the amnestic effects of reserpine in this task. The data show that phosphatidylserine reverses the impairment induced by reserpine in trials performed 24 h and 1 week after training. These results indicate that the memory deficits associated with catecholamine depletion caused by reserpine can be attenuated by acute pre- or post-training or by long-term pretreatment with this phospholipid.
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Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
/
Amnésia
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article