Finding borders between coding and noncoding DNA regions by an entropic segmentation method.
Phys Rev Lett
; 85(6): 1342-5, 2000 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-10991547
ABSTRACT
We present a new computational approach to finding borders between coding and noncoding DNA. This approach has two features (i) DNA sequences are described by a 12-letter alphabet that captures the differential base composition at each codon position, and (ii) the search for the borders is carried out by means of an entropic segmentation method which uses only the general statistical properties of coding DNA. We find that this method is highly accurate in finding borders between coding and noncoding regions and requires no "prior training" on known data sets. Our results appear to be more accurate than those obtained with moving windows in the discrimination of coding from noncoding DNA.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
DNA
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article