Immunology. RNA editing AIDs antibody diversification?
Science
; 289(5485): 1705-6, 2000 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-11001738
ABSTRACT
How do B cells generate the enormous diversity of antibodies that are able to recognize and bind to whichever antigen a B cell might happen to encounter in the body? Several genetic mechanisms that manipulate different combinations of immunoglobulin genes are known. In their Perspective, Neuberger and Scott, highlight another genetic mechanism called RNA editing now shown to be involved in the production of antibody diversity.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Edição de RNA
/
Citidina Desaminase
/
Diversidade de Anticorpos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article