Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance.
Nat Med
; 6(12): 1348-54, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11100119
ABSTRACT
Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8+ T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8+ T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross-presentation by LSEC is CD8+ T cell tolerance rather than immunity. As uptake of circulating antigens into LSEC occurs efficiently in vivo, it is likely that cross-presentation by LSEC contributes to CD8+ T cell tolerance observed in situations where soluble antigen is present in the circulation.
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Base de dados:
MEDLINE
Assunto principal:
Apresentação de Antígeno
/
Linfócitos T CD8-Positivos
/
Endotélio
/
Tolerância Imunológica
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article