Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice.
J Neurosci
; 20(24): 9284-9, 2000 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-11125007
ABSTRACT
The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
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Psicotrópicos
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Síndrome de Abstinência a Substâncias
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Dronabinol
/
Encefalinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article