Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.
J Pediatr
; 138(1): 109-12, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11148522
ABSTRACT
Human beta-defensin-1 (HBD-1) was detected in breast milk in concentrations of approximately 1 to 10 microg/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.
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Base de dados:
MEDLINE
Assunto principal:
Mama
/
Beta-Defensinas
/
Leite Humano
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article