Second-trimester maternal serum alpha-fetoprotein and risk of adverse pregnancy outcome(1).
Obstet Gynecol
; 97(2): 277-82, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11165595
ABSTRACT
OBJECTIVE:
To determine the risk of adverse pregnancy outcome by maternal serum alpha-fetoprotein (MSAFP) level.METHODS:
We followed 77,149 pregnant women and their infants from MSAFP screening in the 15th to 20th week of gestation until 1 year after birth. Information on pregnancy outcome was obtained from national registries. The relative risks (RRs) and 95% confidence intervals (CIs) for adverse pregnancy outcome were estimated according to the level of MSAFP, with adjustment for confounders.RESULTS:
A total of 638 pregnancies resulted in spontaneous abortion, 289 in stillbirth, and 437 in infant death. Compared with women with MSAFP levels at 0.75-1.24 multiples of the median (MoM), those with MSAFP levels greater than or equal to 2.5 MoM had an increased risk of spontaneous abortion (RR 12.5; 95% CI 9.7, 16.1), preterm birth (RR 4.8; 95% CI 4.1, 5.5), small for gestational age (RR 2.8; 95% CI 2.4, 3.2), low birth weight (RR 5.8; 95% CI 5.0, 6.6), and infant death (RR 1.9; 95% CI 1.2, 2.8). Women with MSAFP levels below 0.25 MoM had an increased risk of spontaneous abortion (RR 15.1; 95% CI 9.3, 24.8), preterm birth (RR 2.2; 95% CI 1.3, 3.8), and stillbirth (RR 4.0; 95% CI 1.0, 16.0); those with levels less than 0.5 MoM had an increased risk of infant death (RR 1.9; 95% CI 1.2, 3.0). The increased risk of infant death remained after the subtraction of recognized conditions associated with extreme MSAFP values.CONCLUSION:
Pregnant women with extreme MSAFP values in the second trimester have an increased risk of fetal and infant deaths. Obstet Gynecol 2001;97277-82.
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Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
/
Alfa-Fetoproteínas
/
Aborto Espontâneo
/
Morte Fetal
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article