Synergism of voriconazole and terbinafine against Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.

Weig, M; Müller, F M

Weig, M; Müller, F M.

Afiliação

Weig M; Department of Bacteriology, University of Göttingen, Göttingen, Germany. mweig@gwdg.de

Antimicrob Agents Chemother ; 45(3): 966-8, 2001 Mar.

Article em En | MEDLINE | ID: mdl-11181393

ABSTRACT

ABSTRACT

The synergism of voriconazole (VRC) and terbinafine was studied by using 39 genotypically defined clinical Candida albicans isolates that were cross-resistant to fluconazole and VRC and serial isolates that gradually developed azole resistance. Synergy was noticed in 100% (eight of eight) of the strains that were resistant to VRC. Antagonism was not observed.

Assuntos

Antifúngicos/farmacologia; Candida albicans/efeitos dos fármacos; Infecções por HIV/microbiologia; Naftalenos/farmacologia; Pirimidinas/farmacologia; Triazóis/farmacologia; Infecções Oportunistas Relacionadas com a AIDS/microbiologia; Candidíase/microbiologia; Resistência Microbiana a Medicamentos/fisiologia; Sinergismo Farmacológico; Humanos; Testes de Sensibilidade Microbiana; Faringite/microbiologia; Terbinafina; Voriconazol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazóis / Candida albicans / Infecções por HIV / Antifúngicos / Naftalenos Limite: Humans Idioma: En Ano de publicação: 2001 Tipo de documento: Article

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