Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.
J Am Acad Child Adolesc Psychiatry
; 40(2): 159-67, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11211364
ABSTRACT
OBJECTIVE:
To conduct a post hoc investigation of the utility of a single composite measure of treatment outcome for the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) at 14 months postbaseline.BACKGROUND:
Examination of multiple measures one at a time in the main MTA intent-to-treat outcome analyses failed to detect a statistically significant advantage of combined treatment (Comb) over medication management (MedMgt). A measure that increases power and precision using a single outcome score may be a useful alternative to multiple outcome measures.METHOD:
Factor analysis of baseline scores yielded two "source factors" (parent and teacher) and one "instrument factor" (parent-child interactions). A composite score was created from the average of standardized parent and teacher measures.RESULTS:
The composite was internally consistent (alpha = .83), reliable (test-retest over 3 months = 0.86), and correlated 0.61 with clinician global judgments. In an intent-to-treat analysis, Comb was statistically significantly better than all other treatments, with effect sizes ranging from small (0.28) versus MedMgt, to moderately large (0.70) versus a community comparison group.CONCLUSIONS:
A composite of ADHD variables may be an important tool in future treatment trials with ADHD and may avoid some of the statistical limitations of multiple measures.
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Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Psicometria
/
Transtorno do Deficit de Atenção com Hiperatividade
/
Modificador do Efeito Epidemiológico
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Terapia Combinada
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article