Localization of a new neutralizing epitope on the mumps virus hemagglutinin-neuraminidase protein.
Virus Res
; 74(1-2): 133-7, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11226581
ABSTRACT
Four protein fragments which span the entire hemagglutinin-neuraminidase protein (HN) of mumps virus were expressed in HeLa cells and cell extracts were tested for their capability to induce neutralizing antibodies in mice. Fragment HN3 (aa 213-372) was able to induce the production of hemagglutination-inhibiting and neutralizing antibodies. When a subfragment of HN3, the synthetic peptide NSTLGVKSAREF (aa 329-340 of HN) was used for immunization, hemagglutination-inhibiting and neutralizing antibodies against mumps wild type virus but not against the Urabe Am9 vaccine virus were raised. The peptide could, therefore, contain a new epitope, which may be critical for protective host humoral immune response.
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Base de dados:
MEDLINE
Assunto principal:
Proteína HN
/
Mapeamento de Epitopos
/
Epitopos de Linfócito B
/
Vírus da Caxumba
/
Neuraminidase
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article