In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.
Ann Trop Med Parasitol
; 95(1): 47-57, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11235553
ABSTRACT
The ethanolic, dichloromethane and lyophilized aqueous extracts of Cassia occidentalis root bark, Morinda morindoides leaves and whole plants of Phyllanthus niruri were evaluated for their antimalarial actvity in vivo, in 4-day, suppressive assays against Plasmodium berghei ANKA in mice. No toxic effect or mortality was observed in mice treated, orally, with any of the extracts as a single dose, of 500 mg/kg body weight, or as the same dose given twice weekly for 4 weeks (to give a total dose of 4 g/kg). No significant lesions were observed, by eye or during histopathological examinations, in the hearts, lungs, spleens, kidneys, livers, large intestines or brains of any mouse. At doses of 200 mg/kg, all the ethanolic and dichloromethane extracts produced significant chemosuppressions of parasitaemia (of > 60% for C. occidentalis root bark and Ph. niruri whole plant, and of 30% for M. morindoides leaves) when administered orally. The most active ethanolic extract, that of Ph. niruri, reduced parasitaemia by 73%. The dichloromethane extracts of M. morindoides and Ph. niruri produced similar reductions (74% and 72% chemosuppression, respectively), whereas that of C. occidentalis was slightly less active (60% chemosuppression). Each lyophilized aqueous extract was less active than the corresponding ethanolic extract.
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Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Plasmodium berghei
/
Cassia
/
Euphorbiaceae
/
Rubiaceae
/
Malária
/
Fitoterapia
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article