The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox.
Curr Med Chem
; 8(6): 715-9, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11281850
ABSTRACT
The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid/carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Resinas Vegetais
/
Compostos de Tritil
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article