Interference of propylene glycol with the hole-board test.
Braz J Med Biol Res
; 34(4): 545-7, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11285468
ABSTRACT
Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the head-dipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 +/- 2.37 compared to 33.83 +/- 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 +/- 4.39 to 54 +/- 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.
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Base de dados:
MEDLINE
Assunto principal:
Solventes
/
Ansiolíticos
/
Comportamento Animal
/
Propilenoglicol
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article