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Frequency dependence of spike timing reliability in cortical pyramidal cells and interneurons.
Fellous, J M; Houweling, A R; Modi, R H; Rao, R P; Tiesinga, P H; Sejnowski, T J.
Afiliação
  • Fellous JM; Computational Neurobiology Laboratory, Howard Hughes Medical Institute, Sloan Center for Theoretical Neurobiology, The Salk Institute for Biological Studies, La Jolla California 92037, USA. fellous@salk.edu
J Neurophysiol ; 85(4): 1782-7, 2001 Apr.
Article em En | MEDLINE | ID: mdl-11287500
ABSTRACT
Pyramidal cells and interneurons in rat prefrontal cortical slices exhibit subthreshold oscillations when depolarized by constant current injection. For both types of neurons, the frequencies of these oscillations for current injection just below spike threshold were 2--10 Hz. Above spike threshold, however, the subthreshold oscillations in pyramidal cells remained low, but the frequency of oscillations in interneurons increased up to 50 Hz. To explore the interaction between these intrinsic oscillations and external inputs, the reliability of spiking in these cortical neurons was studied with sinusoidal current injection over a range of frequencies above and below the intrinsic frequency. Cortical neurons produced 11 phase locking for a limited range of driving frequencies for fixed amplitude. For low-input amplitude, 11 phase locking was obtained in the 5- to 10-Hz range. For higher-input amplitudes, pyramidal cells phase-locked in the 5- to 20-Hz range, whereas interneurons phase-locked in the 5- to 50-Hz range. For the amplitudes studied here, spike time reliability was always highest during 11 phase-locking, between 5 and 20 Hz for pyramidal cells and between 5 and 50 Hz for interneurons. The observed differences in the intrinsic frequency preference between pyramidal cells and interneurons have implications for rhythmogenesis and information transmission between populations of cortical neurons.
Assuntos
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Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Células Piramidais / Interneurônios Limite: Animals Idioma: En Ano de publicação: 2001 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Células Piramidais / Interneurônios Limite: Animals Idioma: En Ano de publicação: 2001 Tipo de documento: Article