Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

Killday, K B; Yarwood, D; Sills, M A; Murphy, P T; Hooper, J N; Wright, A E

Killday, K B; Yarwood, D; Sills, M A; Murphy, P T; Hooper, J N; Wright, A E.

Afiliação

Killday KB; Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.

J Nat Prod ; 64(4): 525-6, 2001 Apr.

Article em En | MEDLINE | ID: mdl-11325241

RESUMO

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

Assuntos

Proteína Quinase CDC2/antagonistas & inibidores; Inibidores Enzimáticos/isolamento & purificação; Poríferos/química; Purinas/isolamento & purificação; Animais; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Estrutura Molecular; Purinas/química; Purinas/farmacologia; Análise Espectral

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Base de dados: MEDLINE Assunto principal: Poríferos / Purinas / Proteína Quinase CDC2 / Inibidores Enzimáticos Limite: Animals Idioma: En Ano de publicação: 2001 Tipo de documento: Article

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