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Varicella zoster virus in human and rat tissue specimens.
Annunziato, P W; Lungu, O; Panagiotidis, C.
Afiliação
  • Annunziato PW; Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Arch Virol Suppl ; (17): 135-42, 2001.
Article em En | MEDLINE | ID: mdl-11339542
ABSTRACT
The limited supple of appropriate tissues for study has been an impediment to investigations of varicella zoster virus (VZV) latency. Human dorsal root ganglia (DRG) harboring latent virus are not plentiful and are not amenable to manipulation for studying the events surrounding the establishment, maintenance, and cessation of latency. An alternative to studies in human DRG is the rat model of latency, which appears to provide a reliable method of investigating VZV latency. Other alternatives include studies in other human tissues involved in VZV pathogenesis. In order to improve our understanding of the establishment and cessation of latency, we performed comparative immunohistochemical analysis of chickenpox and zoster skin lesions. This analysis revealed that during primary infection and reactivation productive VZV infection occurs in a variety of cell types and that the major VZV DNA binding protein, ORF29p, is present in peripheral axons early during the course of chickenpox. VZV latency was studied in the rat model by in situ hybridization and compared with similar studies performed in human DRG containing latent virus, confirming that VZV DNA persists in the same sites in DRG of the two species.
Assuntos
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Base de dados: MEDLINE Assunto principal: Ativação Viral / Varicela / Latência Viral / Herpes Zoster Limite: Animals / Humans Idioma: En Ano de publicação: 2001 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Ativação Viral / Varicela / Latência Viral / Herpes Zoster Limite: Animals / Humans Idioma: En Ano de publicação: 2001 Tipo de documento: Article