Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.
Bioorg Med Chem
; 9(4): 1037-44, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11354660
ABSTRACT
A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.
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Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Protetores contra Radiação
/
Catecóis
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article