SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts.
Am J Surg Pathol
; 25(7): 949-55, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11420468
ABSTRACT
SHP-1 is a protein phosphotyrosine phosphatase that plays an important role in modulating intracellular signaling, which regulates cell activation, proliferation, differentiation, and migration. It is a negative regulator of signal transduction induced by a number of cell receptors. Our immunohistochemical examination of paraffin-embedded reactive lymph nodes and lymphoid tissues revealed that B lymphocytes in follicle germinal centers do not express SHP-1. A weak staining of the B cells in the germinal center light zones was detected when an ultrasensitive amplification system was used. In contrast, normal B cells in mantle and marginal zones as well as interfollicular B lymphocytes and plasma cells displayed strong immunoreactivity. This pattern of SHP-1 expression was repeated in small B-cell lymphomas. All cases of mantle cell lymphoma (12 of 12), marginal zone lymphoma (10 of 10), and chronic lymphocytic leukemia/small lymphocytic lymphoma (13 of 13) expressed SHP-1 protein. However, only 1 of 30 cases of grade 1 follicle center cell lymphoma expressed SHP-1. Our observations highlight the biologic functions of SHP-1 and demonstrate that the SHP-1 expression pattern by small B-cell lymphomas reflects the maturation stage of their normal cell counterparts. These results indicate that determination of SHP-1 expression may help in the differential diagnosis of small B-cell lymphomas.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Leucemia Linfocítica Crônica de Células B
/
Linfoma de Células B
/
Proteínas Tirosina Fosfatases
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article