There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia.
Aliment Pharmacol Ther
; 15(8): 1177-85, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11472320
ABSTRACT
BACKGROUND:
The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established.AIM:
To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients.METHODS:
We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos.RESULTS:
Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P < 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04).CONCLUSIONS:
Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.
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Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Claritromicina
/
Dispepsia
/
Amoxicilina
/
Antibacterianos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article