Borna disease: virus-induced neurobehavioral disease pathogenesis.
Curr Opin Microbiol
; 4(4): 467-75, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11495813
ABSTRACT
Studies of the pathogenesis of neurobehavioral diseases following Borna disease virus infections have been increasing rapidly over the past ten years. Recent major advances have included a report of vertical transmission of the virus in its natural host, the horse, and a report of isolation of a novel variant, No/98, in that same species. In rats infected neonatally with the Borna disease virus that lack blood-borne inflammation in the brain, evidence of an "endogenous" brain inflammatory response is abundant, with elevated expression of cytokine and chemokine mRNA. Infection in these rats is also associated with abnormal levels of neurotransmitters, including serotonin and norepinephrine. Data and debate continue to be forthcoming about the role of Borna disease virus in human infection and psychiatric disease.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Borna
/
Vírus da Doença de Borna
/
Encefalopatias
/
Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article