[Familial predisposition to ischemic cardiopathy: role of homocysteine and genetic polymorphism of methylenetetrahydrofolate reductase]. / La predisposizione familiare alla cardiopatia ischemica: ruolo dell'omocisteina e del polimorfismo genetico della metilenetetraidrofolato reduttasi.
Ital Heart J Suppl
; 2(7): 748-53, 2001 Jul.
Article
em It
| MEDLINE
| ID: mdl-11508292
ABSTRACT
Homocysteine represents a risk factor for coronary artery disease determined not only by nutritional habits, but also by the genetic polymorphism of the enzymes involved in its metabolism (i.e. methylenetetrahydrofolate reductase - MTHFR). However, recent prospective studies questioned the initial evidence of a clear epidemiological and pathogenetic link between homocysteine levels and coronary artery disease. Moreover, the relationships between MTHFR polymorphism and coronary artery disease remain unclear. In this paper, the recent literature analyzing the role of homocysteine and MTHFR polymorphism as a risk factor for coronary artery disease has been reviewed.
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Base de dados:
MEDLINE
Assunto principal:
Isquemia Miocárdica
/
Oxirredutases atuantes sobre Doadores de Grupo CH-NH
/
Homocisteína
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
It
Ano de publicação:
2001
Tipo de documento:
Article