Cellular pathophysiology of portal hypertension and prospects for management with gene therapy.
Clin Liver Dis
; 5(3): 851-65, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11565144
ABSTRACT
In summary, regulation of sinusoidal blood flow in normal and injured liver involves structural, cellular, and humoral components. Available data suggest that stellate cells, resident perisinusoidal mesenchymal cells with a histologic orientation in the sinusoid analogous to [figure see text] vasoregulatory pericytes, modulate sinusoidal blood flow. This regulation by stellate cells is most evident in the context of liver injury but may apply also to the normal liver. The endothelin and NO systems are important in modulating stellate cell contractility, and their degree of equilibrium is significant in determining the level of local intrahepatic resistance, especially in the injured liver. Manipulation of either or both of these systems is feasible and effective in experimental models. Such findings have obvious clinical implications and are expected to set the [figure see text] stage for novel gene therapy approaches for treatment of patients with portal hypertension.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Hipertensão Portal
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article